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Inhibitor syndrome

Authoring team

The presence of circulating inhibitors of blood coagulation is indicated by:

  • an increased partial thromboplastin time which cannot be corrected by addition of normal plasma; formally tested as a 30 minute 1:1 mix test - incubation of patient plasma plus an equal volume of normal plasma
  • normal or increased prothrombin time

Increased PTT and PT occurs only when specific coagulation factors fall to below 30% of their normal values.

Two types of circulating inhibitor are recognised:

  • antibodies directed against specific coagulation proteins
  • inhibitors directed against phospholipid function - principally, lupus anticoagulant

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