Circulating inhibitors of blood coagulation may be found in:
The inhibitors are immunoglobulins, usually IgG or IgM, or rarely, IgA, and are targeted against specific coagulation factors. Inhibitors to Factor VIII:C are most common; but Factors V, IX and XI, and Factor VII:von Willebrand's Factor can also be affected. Severe bleeding may result.
Characteristically, the APTT is increased and is not corrected by 1:1 mixture of pooled and normal plasma.
Additionally:
Refs: 1) Chesterman (1992). Haemostatic Failure. Med. Int. 97. 2) Schroeder (1991). Current: med. diag. and tr. Lange.
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