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Management of extrahepatic cholestasis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The management of extrahepatic cholestasis depends on the cause.

There are three general risks when operating on a patient with extra-hepatic cholestasis:

  • hypocoagulability:
    • due to prothrombin deficiency
    • may be corrected by vitamin K administration

  • postoperative renal failure:
    • due to nephrotoxic effects of bile pigments and bowel toxins which escape hepatic detoxification
    • may be prevented with intra- and post-operative use of diuretics e.g. frusemide

  • sepsis:
    • the combination of biliary sepsis and renal failure is usually fatal
    • is prevented with prophylactic antibiotics

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