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Prostaglandins in burn injury

Authoring team

Prostaglandins are produced in the early stages of a burn injury. Key mediators include:

  • prostaglandin E2; it increases vascular permeability
  • leukotrienes B4 to D4 increase vascular permeability
  • prostaglandin I2; vasodilator and increased vascular permeability
  • thromboxane A2; causes vasoconstriction in the zone around the burn, so extending the zone of necrosis

Sources include:

  • neutrophils
  • macrophages
  • platelets - for thromboxane A2

In a sheep burn model, anti-inflammatory drugs reduce the levels of prostaglandins but have little effect on oedema.

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