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Pathology

Authoring team

Histological examination reveals a tuberculosis granuloma with caseating (cheese-like) central necrosis. Epitheloid cells and giant cells of Langhan are present in the granuloma peripheral to the central caseation. There is lymphocyte infiltration of the outer layers and an outer layer of fibrous tissue.

There may be extensive fibrosis in healing lesions.

Reference:

  • Lewinsohn DM, Leonard MK, LoBue PA, et al. Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children. Clin Infect Dis. 2017 Jan 15;64

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