Immune phase
During the immune phase of leptospirosis about 50% of patients develop meningism, of whom about 33% have CSF lymphocytosis and raised protein in the CSF.
Generally the patients then make an uneventful recovery.
A minority of patients go on to develop:
- tender hepatomegaly
- jaundice
- haemolytic anaemia
- oliguric renal failure with microscopic haematuria
- sometimes cardiac involvement with atrial and ventricular dysrhythmias and congestive heart failure
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