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Immunoglobulin solutions (blood transfusion)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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immunoglobulin solutions

Prepared from large pools of donations and contains antibodies against infectious agents to which the donor population has been exposed. Preparations include:

  • normal immunoglobulin
    • contains antibodies to viruses that are common in the population.
    • intramuscular normal immunoglobulin may be used to protect susceptible contacts against hepatitis A, measles or rubella
    • high-dose intravenous immunoglobulin is used as replacement therapy in patients with severe immunoglobulin deficiency and in the treatment of autoimmune diseases such as idiopathic thrombocytopenic purpura (ITP)

  • specific immunoglobulins
    • made from selected donors with high antibody levels to the target of treatment.
    • e.g. - tetanus, hepatitis B and rabies immunoglobulins as well as anti-D immunoglobulin for the prevention of maternal sensitisation to RhD in pregnancy

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