This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Coagulation factors (blood transfusion)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

coagulation factors

Majority of inherited coagulation deficiencies are treated with single factor concentrates (except Factor V and Factor II (prothrombin))

  • fibrinogen concentrate (Factor I) is only licensed in the UK for the treatment of congenital hypofibrinogenaemia
    • its use in acquired hypofibrinogenaemia (e.g. DIC, traumatic haemorrhage, massive transfusion) has reported encouraging results on its effectiveness

Prothrombin complex concentrate (PCC) contains Factors II, VII, IX and X.

  • has replaced FFP as the recommended treatment for rapid reversal of warfarin overdose, with elevated international normalised ratio (INR) and severe bleeding due to its superior efficacy, ease of administration and lower risk of severe allergic reactions or fluid overload
  • do not contain activated clotting factors thus minimizing the risk of causing thrombotic complications
  • may also be used to treat bleeding due to the coagulopathy associated with liver disease
  • dose for reversal of warfarin is 25–50 IU/kg (1)

NICE guidelines on PCC:

  • offer immediate prothrombin complex concentrate transfusions for the emergency reversal of warfarin anticoagulation in patients with either:
    • severe bleeding or
    • head injury with suspected intracerebral haemorrhage.
  • consider immediate prothrombin complex concentrate transfusions to reverse warfarin anticoagulation in patients having emergency surgery, depending on the level of anticoagulation and the bleeding risk.
  • monitor the international normalised ratio (INR) to confirm that warfarin anticoagulation has been adequately reversed, and consider further prothrombin complex concentrate (2)

Reference:


Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.