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Tryptase measurement if anaphylaxis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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After a suspected anaphylactic reaction in adults or young people aged 16 years or older, take timed blood samples for mast cell tryptase testing as follows:

  • a sample as soon as possible after emergency treatment has started
  • a second sample ideally within 1-2 hours (but no later than 4 hours) from the onset of symptoms

After a suspected anaphylactic reaction in children younger than 16 years, consider taking blood samples for mast cell tryptase testing as follows if the cause is thought to be venom-related, drug-related or idiopathic:

  • a sample as soon as possible after emergency treatment has started
  • a second sample ideally within 1-2 hours (but no later than 4 hours) from the onset of symptoms.

Reference:

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