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Situations which require to test for antiphospholipid antibodies (APS)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The following are considered as indications for testing for antiphospholipid antibodies:

  • thrombosis
    • arterial thrombosis before the age of 50
    • unprovoked venous thrombosis before the age of 50
    • recurrent thrombosis
    • thrombosis at an unusual site
    • patients with both arterial and venous thrombotic events
    • any patient admitted with thrombotic microangiopathy of unknown aetiology

  • obstetric manifestation
    • one or more unexplained fetal loss after 10 weeks gestation
    • unexplained severe intrauterine growth restriction
    • early or severe pre-eclampsia
    • three or more spontaneous miscarriages before 10 weeks of gestation

  • patients with SLE
    • at baseline
    • repeat testing before pregnancy, surgery, transplantation and use of oestrogen containing treatments or in the presence of new neurological, vascular or obstetric event (1)

Reference:


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