This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Tubulovillous adenoma of colon

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Tubulo-villous adenomas represent lesions that are histologically intermediate between tubular and villous polyps. These account for the majority of colonic polyps.

Most are pedunculated. The stalk is covered with normal colonic epithelium with a length from 0.5 - 10 cm.

Morphologically they may either be small and pedunculated or sessile lesions.

In general, this type of adenomatous polyp has the least potential for malignant change. The exception is when tubular adenomas occur as part of familial polyposis coli.

Notes:

  • approximately 70% of polyps removed at colonoscopy are adenomas
    • from 70% to 85% of these are classified as tubular (0-25%, villous tissue), 10-25% are tubulovillous (25-75%, villous tissue), and <5% are villous adenomas (75%-100%, villous tissue)

  • most colorectal cancers arise from neoplastic adenomatous polyps (adenomas)
    • adenomas are monoclonal derivatives of a mutated epithelial stem cell. Simple small (<1 cm) tubular adenomas are extremely common and have a low risk of becoming malignant. Only a few acquire the additional genetic alterations that make them grow, develop advanced histological features, and turn to cancer. Advanced adenomas are those that are larger (>1 cm) or that contain appreciable villous tissue or high-grade dysplasia
    • generally accepted that most (>95%) colorectal cancers arise from benign, neoplastic adenomatous polyps (adenomas). Although this adenoma-carcinoma sequence can probably never be proved directly, persuasive data exist indicating that colorectal neoplasia progresses through a continuous process from normal mucosa, to benign adenoma, to carcinoma

  • some degree of dysplasia exists in all adenomas
    • high-grade dysplasia includes the histological changes previously called 'carcinoma in situ, 'intramucosal carcinoma,' or 'focal carcinoma.'
    • approximately 5-7% of patients with adenomas have high-grade dysplasia, and 3-5% have invasive carcinoma at the time of diagnosis
    • increasing dysplasia and, presumably, malignant potential correlate with
      • increasing adenoma size
      • villous component
      • and patient age
    • likelihood of invasive carcinoma also increases with increasing polyp size

Reference:


Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.