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Maddrey's discriminant function (DF)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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NICE suggest the use Maddrey's discriminant function (DF) to determine treatment in people with severe acute alcohol related hepatitis (1)

  • Maddrey's discriminant function (DF) was described to predict prognosis in alcohol-related hepatitis and identify patients suitable for treatment with steroids
    • it is 4.6 x [prothrombin time - control time (seconds)] + bilirubin in mg/dl.
      • to calculate the DF using bilirubin in micromol/l divide bilirubin value by 17
  • DF of 32 or more
    • consider liver biopsy to confirm diagnosis
    • offer corticosteroid treatment

Reference:

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