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Pathogenesis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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90% of patients with Felty's syndrome have HLA-DR4.

It appears that the anaemia is a result of the abnormal spleen. Possible explanations include:

  • sequestration in the spleen
  • humoral factor from the spleen inhibits the bone marrow
  • autoimmune destruction of neutrophils with phagocytosis by the spleen

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