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Precipitation of drugs

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Precipitation may occur due to:

  • drug incompatibility (discard if solution precipitates
  • too concentrated solution or is discoloured)
  • use of saline instead of Water for Injection

Action:

  • check BNF for compatibility
  • use large enough volumes
  • dilute while preparing

Drugs requiring care:

  • Dexamethasone: dilute carefully when preparing
  • Cyclizine: precipitates above concentration 10mg/ml after 24 hours, in saline, and in higher concentrations of Diamorphine
  • Haloperidol: precipitates above concentration of 2mg/ml after 24 hours in mixtures with Diamorphine

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