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There are two distinct types of membranoproliferative glomerulonephritis. They are characterized by capillary basement membrane thickening and mesangial cell proliferation. They are associated with low levels of C3.
Mesangiocapillary glomerulonephritis is a significant cause of nephrotic syndrome in children (accounts for about 8% of cases) and adults (accounts for about 14%).
Treatment of this condition is unsatisfactory and approximately 50% of patients will develop endstage renal failure.
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