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Diagnosis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The criteria for diagnosis of this syndrome has been outlined by the American College of Rheumatology. The six classification criteria identified in the study were:

  • asthma
  • peripheral blood eosinophilia
  • neuropathy
  • pulmonary infiltrates
  • paranasal sinus involvement
  • biopsy showing vasculitis with extravascular eosinophils

The presence of four of these criteria permitted discrimination of Churg-Strauss syndrome from other vasculitidies with a sensitivity of 85% and a specificity of 99.7%.

Laboratory diagnosis is based on tissue biopsy and the antineutrophil cytoplasmic antibody (ANCA) test

  • serologically, the prevalence of ANCA is anti-MPO pANCA 60% and anti-PR3 cANCA 10% and undetected in the remaining 20% (2)

This syndrome is also characterised by elevated levels of IgE.

Reference:

  • (1) Mais AT et al.Arthritis Rheum 1990; 33: 1094-1100.
  • (2) Davies DJ. Small vessel vasculitis. Cardiovascular Pathology 2005; 14 (6): 335-346.
  • (3) Savage COS. Systemic vasculitides.Medicine International 1994;22(2): 53-7.

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