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Resistance to chemotherapy

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Mechanisms of resistance include:

  • high proportion of cells in Go
  • poor tumour penetration
  • rapid drug elimination - if the tumour has p glycoprotein
  • enhanced detoxification by the tumour
  • increased production of target enzymes
  • decreased levels of target enzyme
  • DNA repair

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