This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Pathogenesis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The underlying pathology is not fully understood, however:

  • clinical setting of circulatory disturbance suggests a problem with renal perfusion
  • in animal models, occlusion of renal artery by a clamp or infusion of noradrenaline into the renal artery produces laboratory "ATN"

The renal medulla is often most severely affected in acute tubular necrosis - this may be due to interruption in the perfusion of what is normally a relatively hypoxic part of the kidney. In addition, renal arterioles are prone to excessive vasoconstriction.

There are two phases of ATN described:

  • an initial oliguric phase
  • a polyuric phase, during which the kidney produces large volumes of urine and gradually recovers its ability to concentrate urine.

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.