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Tricyclic antidepressants can be used for in the management of a range of chronic pain syndromes, including:
In many of these conditions 50-90% of patients can be expected to achieve a 50% or greater reduction in pain. The number of patients needed to be treated in order to achieve a 50% reduction in pain in an individual patient are:
The trial evidence is generally for low dose amitriptyline. Other antidepressants may be effective.
For full guidance then see linked item regarding NICE guidance below. Consult the respect Summary of Product Characteristic (SPC) of any medication mentioned before prescribing.
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