This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Duncan's syndrome

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Duncan's syndrome is a rare X-linked recessive lymphoproliferative disorder in which infection by Epstein Barr virus may result in an acutely lethal mononucleosis, development of autoimmune disease, or the delayed appearance of immunoblastic or non-Hodgkin's lymphoma.

It is due to defective T-cell function resulting in failure to recognise and destroy EBV-infected B cells. Affected males may be of any age from 6 months to over 20 years.

The condition may explain the link between EBV infection and Burkitt's lymphoma, the latter resulting when a defective cell mediated response is combined with an 8:14 autosomal translocation.


Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.