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Management of hepatic coagulopathy

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Coagulopathy and haemorrhage are a common consequence of ALF, because of:

  • consumption, and inadequate synthesis, of clotting factors and their inhibitors
  • thrombocytopaenia

The best means of preventing or managing coagulopathy has not been clearly demonstrated:

  • fresh frozen plasma - FFP has not been proved to be effective in this context, and it is currently used only in patients who are bleeding or awaiting an invasive procedure. Infusion of a salt, water and nitrogen load may contribute to the development of cerebral oedema.

  • plasma exchange - it has been suggested that repeated courses of high-volume plasma exchange may prolong survival until liver regeneration begins, or transplantation can be performed. The beneficial effect of plasma exchange has not been confirmed in a randomised controlled trial.

  • parenteral vitamin K - improves coagulation

  • ranitidine - 50 mg in 20 ml given over 2 minutes, three times daily, to reduce stress induced erosions

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