pyrazinamide

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This is the only bactericidal drug which is active against the intracellular forms of Mycobacterium tuberculosis. It is particularly useful in the treatment of tuberculous meningitis because of its good penetration of the blood- brain barrier.

Indications:

  • tuberculosis

Cautions:

  • gout
  • diabetes
  • beware interactions
  • impaired renal function

Contra-indications:

  • liver damage
  • porphyria

Side-effects:

  • nausea and vomiting
  • arthralgia
  • hepatomegaly
  • jaundice
  • hepatotoxicity including fever and anorexia
  • liver failure
  • sideroblastic anaemia
  • urticaria

Routes of administration:

  • oral

The summary of product characteristics should be consulted before prescribing this drug.

Last reviewed 01/2018

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