zona glomerulosa biosynthesis
The zona glomerulosa of the adrenal cortex is involved in the synthesis of mineralocorticoids by the following steps:
- from pregnenolone to progesterone, catalysed by 3-beta-hydroxy dehydrogenase
- to 11-deoxycorticosterone, by 21-beta-hydroxylase
- to corticosterone, by 11-beta-hydroxylase
- to aldosterone by aldosterone synthase
The glomerulosa lacks 17-alpha-hydroxylase, which means that all substrate in this region is directed towards aldosterone.
Last reviewed 07/2021