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Clinical features

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Non-Hodgkin's lymphoma (NHL) is typically disseminated at presentation,

  • painless lymphadenopathy - seen in two-thirds of patients presents which is often generalised. (in contrast the lymphadenopathy of Hodgkin's disease is often localised to a single group of nodes) (1).
  • visceral lymphadenopathy is common, often resulting in heavy tumour burden but with few symptoms.
  • peripheral lymphadenopathy is typically seen in low grade lymphomas (1)

There is more extranodal involvement seen in non-Hodgkin's lymphoma and any organ can be the primary site of NHL

  • gastrointestinal tract is the most common site out of which stomach is the most frequently implicated part
  • NHL is the most common testicular tumour (usually aggressive B-cell tumours) in men older than 60 years (1).

B symptoms indicate an adverse prognosis. B symptoms are:

  • weight loss >10%
  • night sweats
  • pyrexia >38C

Non-Hodgkin's lymphoma may also present with anaemia, infections or purpura.

Reference:

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