This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Pathology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

An excess of unmineralised osteoid is characteristic of both rickets and osteomalacia. Normally, this accounts for less than a quarter of trabecular bone but in osteomalacia and rickets it may approach 100%.

Additionally in rickets there is failure of normal mineralisation of the cartilage matrix in the growth plate. There is an overgrowth of chondrocytes producing a greatly thickened growth plate. Both vascularisation and calcification are impaired in the underlying zone of maturation.

 

Reference

  • Chesney RW. Bone structure, growth, and hormonal regulation. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson textbook of paediatrics, 17th ed. Philadelphia, PA: Saunders; 2004.

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.