pancytopenia occurs in over 50% of cases - a result of marrow failure and splenic sequestration
anaemia is common
thrombocytopenia and neutropenia found in 75% of cases
peripheral blood smear shows small numbers of "hairy cells" characterised by numerous cytoplasmic projections; less frequently, the hairs dominate the smear
hairy cells stain positively for tartrate resistant acid phosphatase and express CD11c and CD25
hairy cells often infiltrate the red pulp of the spleen
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