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Trial of St John's wort in depression

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

324 patients with mild to moderate depression were recruited from 40 outpatient clinics in Germany.

Patients were randomized to:

  • 75 mg imipramine twice daily, or
  • 250 mg hypericum extract ZE 117 twice daily

The trial was double-blind.

Patients were assessed in the following ways:

  • Hamilton depression rating scale
  • clinical global impression scale
  • patient's global impression scale

Reference:

  • Woelk, H. (2000) Comparison of St John's wort and imipramine for treating depression: randomised controlled trial. BMJ, 321, 536-9

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