The International Stroke Trial (IST) investigated the role of aspirin and/or heparin in the acute treatment of presumed ischemic stroke.
19,435 patients presenting within 48 hours with a diagnosis of ischaemic stroke were randomised to aspirin, heparin, both or neither. The trial was not blind.
The primary outcomes were:
The aim was to provide reliable evidence on the safety and efficacy of aspirin and of subcutaneous heparin.
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