verapamil has a significant prolactin releasing effect - a study revealed that 8.5% of male patients treated with verapamil had increased prolactin levels with a concomitant reduction in testosterone levels (1) - this prolactin releasing effect is not significant with other calcium antagonists
verapamil may lead to hyperprolactinaemia via antagonism of N-type calcium channels and consequent decrease in central dopamine production
Reference:
1) Romeo JH et al. Hyperprolactinaemia and verapamil: prevalence and potential association with hypogonadism in men. Clin Endocrinol (Oxf) 1996;45:571-5.
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