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Neurological manifestations

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Neurological involvement is reported in 25 to 75% of lupus patients (1).

  • may affect any parts of the nervous system
  • a study revealed that in patients with neurological symptoms, the incidence of elevated APL was approximately two times higher than in those without neurological manifestations (1)

Neurological manifestations may include a wide variety of lesions such as:

  • peripheral neuropathy - including rarely, the Guillain Barre syndrome
  • seizures - grand mal most common; other types rare
  • movement disorders such as chorea and choreoathetosis
  • impaired memory, perception, orientation and intellectual function
  • severe headaches
  • aseptic meningitis
  • stroke and transient ischemic attacks (TIA) - may be related to antiphospholipid antibody syndrome or vasculitis
  • transverse myelitis with spastic paraparesis
  • limbic encephalitis-type picture (1)
  • psychological disturbance:
    • particularly depression and anxiety
    • particularly in recently diagnosed patients and those with disfiguring skin lesions

Reference:

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