Last edited 05/2019
AL amyloidosis is associated with the deposition of amyloid light (AL) fragments - the molecular weight varying from 5000 to 25000. It may complicate almost any form of clonal B-cell dyscrasia
It most commonly affects mesenchymal tissues, and the organs most often affected are the heart, spleen, kidneys, bone marrow, nerves, muscles, skin, and gut.
Cardiac involvement is clinically significant in 30% of patients, but may be histologically present in 90%
The median survival is worse than that seen in patients with AA amyloidosis.