The renal mineralocorticoid receptor has a similar affinity for cortisol and aldosterone. Aldosterone exerts its specific mineralocorticoid effect because 11beta-hydroxysteroid dehydrogenase type 2 inactivates cortisol within the kidney.
Loss of 11beta-hydroxysteroid dehydrogenase type 2 allows cortisol to exert a strong mineralocorticoid effect resulting in:
Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.