This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Ticlopidine

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

This drug acts by blocking the platelet ADP receptor, which promotes aggregation when activated.

  • currently used in the UK, in combination with aspirin, to prevent thrombosis with coronary stents
  • 1-2 % incidence of neutropaenia in patients taking ticlopidine
  • current evidence suggests that ticlodipine is more effective than aspirin in preventing a stroke in patients who have already had a transient ischaemic attack or previous stroke - however because of ticlodipine's potential side effect of bone marrow suppression, aspirin remains the treatment of choice in secondary prevention (1)
  • ticlodipine has uncommon (0.5-3%) but very serious haematological toxicity including neutropaenia, thrombocytopaenia, thrombotic thrombocytopaenia purpura and (very rarely) aplastic anaemia (2); gastrointestinal side effects and rash are common
  • ticlopidine is inactive and metabolised to active metabolites in the liver

The summary of product characteristics should be consulted before prescribing this drug.

Reference:

  1. Drug and Therapeutics Bulletin (1999), 37 (8), 59-61.
  2. Patrano C et al.Platelet-active drugs: the relationships among dose, effectiveness, and side effects. Chest 2001;119:39S-63S

Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.