This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Glyburide for gestational diabetes

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Sulphoylurea drugs are contraindicated in pregnancy and gestational diabetes. Early experience of sulphonylureas in pregnancy resulted in neonates with prolonged hyperinsulinaemic hypoglycaemia and animal studies demonstrated direct toxic and teratogenic effects.

Glyburide is a sulphonylurea that does not seem to cross the placenta and a randomised controlled trial in 404 women with gestational diabetes gave successful results in 96% without any of the feared complications. Women began the therapy after 11 weeks of pregnancy so it was not possible to address concerns over teratogenicity and the study was also insufficiently powered to examine fetal or perinatal mortality.

Reference:

  • Editorial NEJM 2000; 343(16):1178-1179

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.