This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Clonidine

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Centrally acting antihypertensives reduce arteriolar muscular tone by reducing sympathetic activity.

First generation drugs, such as clonidine and methydopa, act as alpha-2 adrenoceptor agonists resulting in inhibition of the sympathetic nuclei in the rostroventrolateral medulla. Side-effects of these agents preclude their widespread use as first line hypertensive agents.

A second generation centrally-acting antihypertensive was subsequently introduced

  • Moxonidine is an agonist at the imidazoline I1 receptor
    • the I1 receptor is found in the rostroventrallateral medulla and in the kidney
    • stimulation of I1 results in reduced sympathetic tone and a lowering of blood pressure

The summary of product characteristics should be consulted before prescribing this drug.

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.