This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Clozapine (trial in refractory schizophrenia)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

423 hospitalised patients with refractory schizophrenia were randomised to clozapine or standard treatment with haloperidol.

57% of clozapine patients and 61% of haloperidol patients continued with the assigned drug for the whole year.

Clozapine patients had 5.4% lower symptom scores (score 79.1 vs. 83.6, P=0.02).

Clozapine patients needed fewer days of inpatient treatment (143.8 vs. 168.1, P=0.03).

Despite a higher drug bill in the clozapine group the annual total cost was less because of the fewer inpatient days.

Reference:

  • Rosenheck R. et al (1997). A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. NEJM, 337, 809-15.

Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.