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Skin lesions associated with Langerhans cell histiocytosis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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The skin lesions associated with Langerhans cell histiocytosis are fine erythematous papules surmounted by a scale. They resemble seborrhoeic dermatitis except that they are papular and may be haemorrhagic. The papules are red-brown. They frequently occur on the scalp but may be generalised. They may become confluent forming a greasy scale. Frank ulcers may occur behind the ears and in the groin.

Skin lesions are seen in virtually all patients with Letterer-Siwe disease and in 30 - 50% of those with Hand-Schuller-Christian disease.

Skin manifestations of eosinophilic granulomas are rare, but when they occur, the papules are larger and there may be nodules.


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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