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Dosage of ACE inhibitors in heart failure

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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  • for example, captopril - test dose of 6.25mg; then, if tolerated, 6.25-25mg/8h PO.

When using an ACE inhibitor, a loop diuretic should be retained but amiloride should not. This is because the combination of a potassium sparing diuretic and amiloride may cause hyperkalaemia and therefore potential heart block.

There is evidence, via the ATLAS study, that a high dose ACE inhibitor may be a more effective treatment intervention than a low dose ACE inhibitor.

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