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Acute liver injury following turmeric use

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Curcumin supplements have shown some evidence of benefit in the treatment of osteoarthritis (1).

Curcumin is extracted from the plant turmeric (Curcuma longa)

  • content of curcuminoids in turmeric powder is 3.14%, which is used as a spice in cuisines of the Middle East and Indian subcontinent (2) - much higher amounts of curcumin are present in over the counter supplements than is found in turmeric powder (3)

A case report describes a curcumin-induced hepatocellular DILI (drug-induced liver injury) in a 78-year old female admitted with jaundice, with a one-month latency (3)

A systematic review of case reports in Tuscany concluded that "evaluation of Italian cases of Curcuma longa-induced acute hepatitis and the systematic review of literature confirmed the association between Curcuma longa and liver injury.." (4)

Reference:

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