This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Adrenaline, anaphylaxis and drug interactions

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The use of adrenaline in anaphylaxis is complicated by chronic pre-treatment of the patient in the following situations:

  • patients who are taking tricyclic antidepressants or monoamine oxidase inhibitors should receive only 50% of the usual dose of adrenaline because of an interaction which is potentially dangerous. Some fluorohydrocarbons used as refrigerants as well as cocaine sensitise the heart to adrenaline and are contraindications to its use
  • also half doses of adrenaline (epinephrine) may be safer for patients on a beta blocker (1)


  1. Resuscitation Council (UK). The Emergency Medical Treatment of Anaphylactic Reactions for First Medical Responders and for Community Nurses Revised January 2002, May 2005.

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.


Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.