Reactive amyloidosis usually occurs with a chronic infection or inflammatory disease such as tuberculosis, osteomyelitis, rheumatoid arthritis, or Crohn's disease. It also occurs in malignancy, e.g. Hodgkin's lymphoma - non-Hodgkin's lymphoma associated with primary amyloidosis - and with familial Mediterranean fever. In this form of amyloidosis AA amyloid fibrils are deposited in the tissues.
Organs most often affected are the parenchymal tissues, e.g. kidneys, spleen and liver. Common presentations are proteinuria, nephrotic syndrome, and renal failure. A few patients have hepatosplenomegaly.
Prognosis is related to the degree of renal impairment.
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