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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Muscular, medium-sized arteries are involved throughout the skin and most viscera.

There is inflammation of all layers of the vessel wall with fibrinoid necrosis and inflammatory cell infiltrates. (1)

Tissue damage is due to ischaemia caused by:

  • acute thrombosis of the inflamed artery
  • arterial stenosis due to fibrosis

The vasculitis may be due to deposition of immune complexes in the vessel wall.


1. Polyarteritis Nodosa - a contemporary overview. U.S. National Library of Medicine 2016. Available from:

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