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Hypersensitivity reactions

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The original classification by Gell and Coombs is still very useful today. They classified hypersensitivity reactions as four different types.

  • Type I - IgE mediated; immediate hypersensitivity reaction.

  • Type II - hypersensitivity reaction takes place intravascularly.

  • Type III - immune complex mediated.

  • Type IV - in this form of hypersensitivity the immune response is mediated by the action of the lymphocytes rather than by antibody.

Since this classification however, two further reactions Type V and Type VI have been described.

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