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Corticosteroid injections and risk of fracture

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

A cohort study of 7197 patients over a 4-year period was undertaken to assess whether there was a higher fracture risk associated with cumulative doses of injected corticosteroid (CSI) (1)

  • study found that higher fracture risk was not associated with the cumulative dose of injected corticosteroid, regardless of osteoporosis status
  • study authors concluded that:
    • in this cohort study of cumulative injected corticosteroid dose and risk of subsequent fracture, no association was observed, including in patients with a preexisting diagnosis of osteoporosis
    • treatment of painful conditions with CSI should not be withheld or delayed owing to concern about fracture risk


  1. Sytsma TT, Thomas S, Fischer KM, Greenlund LS. Corticosteroid Injections and Risk of Fracture. JAMA Netw Open. 2024;7(5):e2414316. doi:10.1001/jamanetworkopen.2024.14316

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