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Differential diagnosis

Authoring team

The differential diagnosis of Churg-Strauss includes:

polyarteritis nodosa:

  • there is no eosinophilia
  • hypereosinophilic syndrome:
    • the eosinophilia is more severe than in Churg-Strauss
    • there is diffuse central nervous system disease, thromboembolism, hepatosplenomegaly, and thrombocytopaenia
    • response to steroids is poor
  • Wegener's granulomatosis:
    • the eosinophilia and allergic features seen in Churg- Strauss are absent
    • Wegener's granulomatosis is more destructive of the upper and lower respiratory tracts

Reference

  1. Mahr A et al. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): evolutions in classification, etiopathogenesis, assessment and management. Curr Opin Rheumatol. 2014 Jan;26(1):16-23.

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