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Trial of efficacy of synthetic vs. animal surfactant

Authoring team

GESTATION: A RAMDOMISED TRIAL

The trial compared the efficacy of a synthetic surfactant (Pumactant) and an animal-derived surfactant (Poractant alfa) in premature neonates with respiratory distress syndrome.

The primary end-point was duration of high-dependency care. The secondary end-point was mortality.

Reference:

  • 1) Ainsworth, SB, Beresford, MW. et al. (2000). Pumactant and poractant alfa for treatment of respiratory distress syndrome in neonates born at 25-29 weeks' gestation: a randomised trial. Lancet, 355, 1387-92

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