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RADIANCE trial

Authoring team

The RADIANCE trial was a prospective, randomised, double-blind and placebo-controlled study which investigated the effect of withdrawing digoxin from patients with heart failure.

All patients were in sinus rhythm and had stable class II/III NYHA heart failure treated with diuretics, ACE inhibitors and digoxin.

93 patients were randomised to withdrawal of digoxin and 85 continued with digoxin.

Reference:

  • 1) Milton Packer, Mihai Gheorghiade, James B. Young, Peter J. Costantini, Kirkwood F. Adams, Robert J. Cody, L. Kent Smith, Lucy Van Voorhees, Lynn A. Gourley, M. King Jolly, for the RADIANCE Study. (1993) Withdrawal of Digoxin from Patients with Chronic Heart Failure Treated with Angiotensin-Converting-Enzyme Inhibitors. N Engl J Med, 329, 1-7.

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