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Leukocyte adhesion deficiency

Authoring team

Leukocyte adhesion deficiency is a genetic condition resulting from impaired production of a beta chain coding for an adhesion molecule(1).

Without correct function of the latter, leukocytes are unable to traverse endothelial cells to the region of acute inflammation. Sufferers are predisposed to recurrent bacterial infections.

Reference:

  • (1) Anderson, D.C., Springer, T.A. (1987). Leukocyte adhesion deficiency. An inherited defect in the Mac-1, LFA-1, p150,95 glycoproteins. Ann. Rev. Med. 38, 175.

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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