Diagnosis
- measurement of ANCA titre:
- about 50-70% of patients have ANCA (1)
- the ANCA found in microscopic polyangiitis is usually p-ANCA (directed to myeloperoxidase (MPO)) (1) - MPO-ANCA give a perinuclear staining pattern on immunofluorescence.
- MPO-ANCA are found in microscopic polyangiitis (70%) but PR3-ANCA (ANCA directed against proteinase 3 giving a granular cytoplasmic staining pattern on immunofluorescence) can also occur (2)
- MPO-ANCA are found in microscopic polyangiitis (70%) but PR3-ANCA (ANCA directed against proteinase 3 giving a granular cytoplasmic staining pattern on immunofluorescence) can also occur (2)
- the ANCA found in microscopic polyangiitis is usually p-ANCA (directed to myeloperoxidase (MPO)) (1) - MPO-ANCA give a perinuclear staining pattern on immunofluorescence.
- about 50-70% of patients have ANCA (1)
- renal biopsy
- extracapillary glomerulonephritis is a feature in 90% of cases
- similar findings to those seen in Wegener's granulomatosis but no granulomata are found
- extracapillary glomerulonephritis is a feature in 90% of cases
Notes:
- the relative prevalences of cANCA and pANCA vary with different reviews. Jennette JC et al state that serologically, the prevalence of ANCA is anti-MPO pANCA 50% and anti-PR3 cANCA 40%, with negative results in 10% (3)
Reference:
- (1) Bosch X et al. Antineutrophil cytoplasmic antibodies. The Lancet 2006;368 (9533): 404-418.
- (2) Harper L, Weidanx F. Small vessel vasculitides. Medicine 2006; 34 (11): 456-463.
- (3) Jennette JC et al. Microscopic polyangiitis (microscopic polyarteritis). Semin Diagn Pathol 2001;18: 3–13.
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