This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Aetiology

Authoring team

The aetiology of this condition is unknown.

Goodpasture's syndrome often starts after an upper respiratory tract infection (there is an association with influenza A2 virus)

  • during the 1919 influenza epidemic, Goodpasture described a disease association between pulmonary hemorrhage and rapidly progressive glomerulonephritis (RPGN)
    • in 1977, Lerner et al. discovered that the sera and/or kidneys of some patients with this syndrome contained antibodies against the glomerular basement membrane

There is a strong association with HLA-DR2 (about 90%). A more severe form of the disease occurs in patients who also have HLA-B7.

Reference:

  1. E. Goodpasture. The significance of certain pulmonary lesions in relation to the etiology of influenza. Am J Med Sci 1919; 158:863–870

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.